Fig. 2
From: Interleukin-35 on B cell and T cell induction and regulation
IL-35 regulation in Breg cells. The immunosuppressive cytokine IL-35 induces the expansion of Breg cells, which secrete IL-35 to protect from autoimmune disease. Secretion of B cell–derived IL-35 seems to have an autocrine role through activation of the IL-35 receptor (IL-12Rb2 and IL-27Rb) to expand or induce Breg cells. B cell–derived IL-35 also acts on T cells to induce a Foxp3+ Treg cell population