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Table 1 Effect of resveratrol (5, 10 and 20 mg/kg) on different neurological scoring tests on 21st day

From: Resveratrol protects against ICV collagenase-induced neurobehavioral and biochemical deficits

Behavioral test Horizontal Bar test Cylinder Test Spontaneous motility Forelimb flexion Righting reflex
Group
Control 4.0 ± 0.0 43.4 ± 6.9 1.0 ± 0.0 1.0 ± 0.0 1.0 ± 0.0
Sham 3.8 ± 0.4 42.8 ± 2.9 0.8 ± 0.2 1.0 ± 0.0 1.0 ± 0.0
Control +RSV (20 mg/kg) 3.8 ± 0.4 41.6 ± 2.8 1.0 ± 0.0 1.0 ± 0.0 1.0 ± 0.0
ICV-collagenase (1 IU) 0.6 ± 0.4# 10.3 ± 3.0# 0.2 ± 0.2# 0.2 ± 0.2# 0.2 ± 0.0#
ICH+ RSV (5 mg/kg) 1.8 ± 0.4 23.8 ± 5.9 0.4 ± 0.2* 0.6 ± 0.2 0.0 ± 0.0
ICH + RSV (10 mg/kg) 2.8 ± 0.4* 34.2 ± 5.2* 0.8 ± 0.2* 0.6 ± 0.2 0.2 ± 0.2
ICH + RSV(20 mg/kg) 3.4 ± 0.4* 38.4 ± 6.2* 1.0 ± 0.0* 1.0 ± 0.0* 1.0 ± .00*,$
  1. Values are expressed as mean ± SEM. ICH indicates ICV-collagenase treated rats; RSV, resveratrol. One way ANOVA followed by Tukey’s multiple comparison tests was applied. #p < 0.05 as compared to naïve group. *p < 0.05 as compared to ICV-collagenase group. $p < 0.05 as compared to ICH + RSV (5 mg/kg) group