Ezetimibe reduces cholesterol content and NF-kappaB activation in liver but not in intestinal tissue in guinea pigs

Table 2 HMG-CoA reductase activity in liver microsomes, Vmax and Km in liver membranes in guinea pigs on chow or cholesterol diet with or without Ezetimibe

Diet	n	HMG-CoA reductase [pmol/mg Protein/min]	Vmax [μg / mg Protein]	Km [μg / ml Medium]
Chow	11	22,2 ± 7,2	1,22 ± 0,21	23,6 ± 4,05
Ezetimibe	4	57,0 ± 28,7^a	1,39 ± 0,11	21,56 ± 1,8
Cholesterol	12	1,2 ± 0,5^b	1,8 ± 0,45	35,50 ± 7,5
Cholesterol + Ezetimibe	7	25,4 ± 7,0^c	1,76 ± 0,35	32,24 ± 7,0

^asignificantly different from Chow-diet, ^bsignificantly different from Chow and Ezetimibe diet, ^csignificantly different from Ezetimibe and Cholesterol diet

ISSN: 1476-9255