Fig. 7

High-density lipoproteins reduce collagen deposition in murine fibroblasts via immunomodulatory and direct anti-fibrotic properties. Bar graphs represent the mean ± SEM of the ratio of the absorbance at 540 nm of Sirius Red-stained murine fibroblasts towards the absorbance at 495 nm of crystal violet-stained murine fibroblasts cultured a) in the absence (basal) or presence of splenocytes isolated from C57BL/6, ob/ob, ob/ob Ad.Null and ob/ob Ad.A-I mice, as indicated, at a ratio of 10 splenocytes to 1 fibroblast for 24 h, with n = 5-6/group and *p < 0.05, **p < 0.005, ***p < 0.0005, and ****p < 0.0001 and b) depict the mean ± SEM of the ratio of the absorbance at 540 nm of Sirius Red-stained murine fibroblasts towards the absorbance at 495 nm of crystal violet-stained murine fibroblasts in the presence of TGF-ß1 with/out HDL supplementation for 24 h, with the different groups as indicated: n = 12/control, HDL, and TGF-ß1 + HDL groups and n = 9/TGF-ß1 group with *p < 0.05, **p < 0.01 and ****p < 0.0001