Fig. 3

The effects of Abn-CBD treatment on microscopic damage score and histology. TNBS-treated mice were given O-1918, AM251, AM630 (all at 5 mg/kg) and/or Abn-CBD (5 mg/kg) twice daily for 3 days. Microscopic damage score (a and b) and histological appearance of the hematoxylin/eosin stained tissue (c) were determined at the end of the experiment, 24 h after the last dose of drug. TNBS-treated mice displayed severe mucosal damage as well as an increase in lymphocyte and neutrophil infiltration. a Mucosal damage was significantly reduced by Abn-CBD treatment and reversed by addition of O-1918; *, p < 0.05, when compared to any other treatment group. b Mucosal damage was significantly reduced by Abn-CBD treatment and partly reversed by administration of AM251; *, p < 0.05, when compared to TNBS alone. Data were analyzed with one-way ANOVA with Tukey’s post-hoc test, n = 4-5/group. Scale bar in C. = 100 μm