Effects of CpG Oligodeoxynucleotide 1826 on transforming growth factor-beta 1 and radiation-induced pulmonary fibrosis in mice

Table 1 The serum TGF-β1 at different times (days) (ng/ml, \( \overline{x}+s \))

Group	Mice(n)	1 d	5 d	15 d	30 d	90 d
Control	6	107.511 ± 10.032	103.027 ± 11.797	117.598 ± 16.270	108.595 ± 17.082	123.615 ± 17.491
RT	6	137.800 ± 9.694^a	171.247 ± 13.449^ac	203.633 ± 9.775^ac	237.516 ± 11.589^ac	174.161 ± 16.690^ac
CpG RT + CpG	6 8	116.985 ± 17.541 120.275 ± 21.534	122.065 ± 22.832 138.600 ± 7.388^ab	105.213 ± 19.539 157.809 ± 12.353^abc	112.231 ± 14.892 180.615 ± 13.091^abc	102.731 ± 16.177 146.649 ± 12.004^bc

Notes: F = 4.959, P < 0.05 on days 1; F = 23.1, P < 0.05 on days 5; F = 51.743, P < 0.05 on days 15; F = 114.643, P < 0.05 on days 30; F = 30.874, P < 0.05 on days 90; ^a P < 0.05 versus control at t = 5.318, 9.432, 11.103, 15.298, 5.913, 6.260, 4.822 and 8.197; ^b P < 0.05 versus RT at t = 5.212, 7.126, 7.972 and 3.785; ^c P < 0.05 versus CpG at t = 4.546, 11.034, 16.263, 8.692, 5.573, 8.448 and 6.167
Abbreviations: CpG cytosine-guanine, RT irradiation, n number, d days

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