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Fig. 5 | Journal of Inflammation

Fig. 5

From: The synthetic cannabinoid WIN55,212-2 mesylate decreases the production of inflammatory mediators in rheumatoid arthritis synovial fibroblasts by activating CB2, TRPV1, TRPA1 and yet unidentified receptor targets

Fig. 5

Influence of WIN55212-2 mesylate (WIN, 10−12M to 10−5M) on adhesion under normoxia and proliferation under hypoxia of OA and RA synovial fibroblasts. a Impact of WIN on OASF and RASF adhesion to fibronectin. b Impact of WIN on OASF and RASF proliferation. The general linear model with Bonferroni correction was used for all comparisons. The dotted line represents the control level without (tissue culture medium only) which was set to 100 %. Fig. 4a, b: Data are given as mean ± sem. The boundary of the box closest to zero indicates the 25th percentile, the line within each box indicates the median and the upper boundary of the box the 75th percentile; WIN data are given as median. Error bars below and above the boxes indicate the 10th and 90th percentiles. Fig. 4a: ***p < 0.001 for comparisons vs control. Fig. 4b: ***p < 0.001 for comparisons vs control, (WIN 2 μM to 10 μM only)

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Journal of Inflammation

ISSN: 1476-9255

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