Fig. 1

Similar body weights and colon weight-length-ratios of Clca1 ^-/- and WT mice. a From day 7 on, both DSS-treated genotypes showed a continuous weight loss to 88.9 ± 0.9 % and 89.5 ± 1.6 % at day 9 whereas the unchallenged mice continued a slight overall weight gain to 103.2 ± 0.9 % and 102.2 ± 1.2 % for Clca1 ^-/- and WT mice, respectively. At day 4, DSS-treated WT mice had higher body weights than the WT controls and the DSS-challenged Clca1 ^-/- group, the relevance of which, however, remains questionable. n = 10 – 30 per group. b The colon weight-length-ratios increased during DSS colitis compared to unchallenged controls from 0.027 ± 0.001 and 0.027 ± 0.001 to 0.044 ± 0.002 and 0.043 ± 0.001 for Clca1 ^-/- and WT, respectively, however, with no difference between the genotypes. n = 10 per group. ^# p < 0.05 vs. the unchallenged control group. *p < 0.01 between the genotypes