Fig. 5

Macrophage appearance precedes significant IL-18 expression in damaged brain regions. Macrophages significantly appear at 24 h following seizure onset in the piriform cortex (a), thalamus (b), and dentate gyrus (e). Macrophages in the CA1 (c) and CA3 (d) significantly increase by 48 h. Pearson’s analysis shows a positive correlation between IL-18 expression and macrophage appearance in the CA1, CA3 and dentate gyrus regions of the hippocampus, thalamus and piriform cortex (f). Data are given as a macrophage appearance score and reported as median ± Q1 and Q3 and were analyzed using a Kruskal-Wallis test with a post-hoc Dunn’s Multiple Comparison test. (n = 3 or 4 for each time point/ brain region; * p < 0.05, ** p < 0.01)