Fig. 7
Hypothesized regulatory networks among Zfp36l1, Zfp36l2, Mkp-1, and p38 MAPK in RAW264.7 cells. Under resting conditions, Zfp36l1 and Zfp36l2 interact with Mkp-1 mRNA 3’UTR and destabilize it, and the cells are sensitive to stimuli such as LPS under low Mkp-1 expression. During early LPS stimulation for 15 min, Zfp36l1 and Zfp36l2 were phosphoprylated and resulted in the decrease of their mRNA destabilization function; so that Mkp-1 mRNA and protein were induced to inactivate LPS-stimulated p38. pppGm7: 7-methylguanosine cap. P: phosphate group