Figure 3

Pentoxifylline (PTX, 50 and 100 mg/kg) treatments of diabetic rats for 5 days significantly decrease IL-6 levels in rat paws, at both doses, as related to untreated-diabetic animals and to normal controls (non-diabetic animals). Glibenclamide (GLI, 5 mg/kg) was included for comparisons. Measurements were done in homogenates and the values are means ± SD from groups of three animals each. a. vs. normal controls, q = 233.9; b. vs. normal controls, q = 98.47; c. vs. untreated-diabetic group, q = 332.4; d. vs. normal controls, q = 92.99; e. vs. untreated-diabetic group, q = 326.9; f. vs. normal controls, q = 80.20; g. vs. untreated-diabetic group, q = 314.1 (One-way ANOVA followed by Tukey’s as the post hoc test).