Figure 4

Effect of chronic intermittent hypobaric hypoxia (CIHH) pretreatment on TNF-α (A), IL-17 (B), IFN-γ (C) and IL-4 (D) protein expression in synovial tissue of collagen-induced arthritis rat. Representative photomicrographs of protein expression in synovial tissue of Control (a), CIA (b), CIHH+CIA (c) and IHS (d). Brown staining indicates protein expression in cytoplasm (arrow). CIA: collagen-induced arthritis groups; CIHH+CIA: CIHH treated CIA group; HIS:Immunohistochemistry score of protein expression; Data were expressed as mean ± SEM, n = 6 for each group, * p<0.05 vs CIA,# p<0.05 vs Control (Immunohistochemistry staining × 400).