Figure 6From: Orphan nuclear receptor NR4A2 induces transcription of the immunomodulatory peptide hormone prolactin PRL regulates expression of genes involved in inflammation, proliferation, and cell survival. A. K4IM synoviocytes were treated in triplicate with TNF-α (10 ng/mL) or PGE2 (1 μM) for 24 hours. PRL-R was measured by RT-qPCR. ***p < 0.001. B. cDNA from K4IM synoviocytes treated with rhPRL (1 μg/mL, 24 hours) was analyzed on JAK/STAT signaling pathway qPCR arrays. Gene expression data was normalized to 3 housekeeping genes and the genes most highly regulated by rhPRL are displayed.Back to article page