Figure 6

The effect of the isolated compound and plant extract on AP-1. The isolated labdane diterpenoid (Lab) and the extract (OL) were tested for activity against the c-Jun component of AP-1 (n = 3) in PHA stimulated PBMCs. Lab significantly (p < 0.05) inhibited AP-1 in PBMCs at 50 μM. NAC (100 μg/mL) was used as positive control and significantly inhibited AP-1 (a). Co-treatment with NAC resulted in stimulation of AP-1 production. At 25 μg/mL, the plant extract significantly stimulated AP-1 in PBMCs (p < 0.05).