Figure 4
From: Positive allosteric modulation of the adenosine A2a receptor attenuates inflammation
Enhancement of agonist binding to hA 2a R. Equilibrium binding of [3H]CGS 21680 to hA2aR in the presence of AEA061 (10 μM) and vehicle control is shown. CHO-hA2aR membranes were incubated with ADA and varying concentrations of [3H]CGS 21680 in the presence and absence of AEA061. Bmax values: control = 152 fmol/mg; AEA061 (10 μM) = 470 fmol/mg. Values are mean ± SD of results of one representative experiment performed in triplicate.