Figure 1

Brain morphological changes in the frontal cortex after 8 min of cerebral forebrain ischemia and reperfusion in normoglycemic and hyperglycemic animals. (A,D) Typical appearance of brain tissues in normo- and hyperglycemic sham control animals. (B,E) Brain edema and neuronal swelling in normoglycemic ischemic animals after 3 and 6 days of reperfusion. (C,F) Enhanced brain edema and neuronal death in hyperglycemic animals after 3 and 6 days of reperfusion. Arrows indicate tissue or neuronal swelling; arrowheads denote neuronal death. Magnification 400X, bar = 20 μm.