Figure 4
From: Induction of acute lung inflammation in mice with hemorrhagic shock and resuscitation: role of HMGB1
Inhibition of HMGB1 does not show protection to gut injury in the early phase of HS/R in mice. A. Mice were subjected to sham surgery, HS/R, or HS/R plus A-Box (300 μg, i.p.) given at the beginning of the transfusion of shed blood). Gut permeability and bacteria translocation were determined at 30 min and 2 hrs after completion of resuscitation by measuring circulating FD4 or circulating LPS, respectively. Five mice in each group, *p < 0.05 vs sham. B. Wild type (WT) and TLR4-/- mice were subjected to either sham or HS/R. Gut permeability and bacteria translocation were determined at 30 min and 2 hrs after completion of resuscitation by measuring circulating FD4 or circulating LPS, respectively. Five mice in each group, *p < 0.05 vs related sham group.