Table 1 Contrasts of ANCOVA at 6 hours post-dose after ex vivo LPS challenge
| Â | 0.5 ng/kg vs placebo | 1 ng/kg vs placebo | 2 ng/kg vs placebo | |||
|---|---|---|---|---|---|---|
Estimated difference(%) | p-value | Estimated difference(%) | p-value | Estimated difference(%) | p-value | |
TNF-α | -13.6 | 0.6256 | -66.4 | 0.0005 | -74.7 | <0.0001 |
IL-1β | -30.0 | 0.1606 | -65.8 | <0.0001 | -84.7 | <0.0001 |
IL-6 | 34.8 | 0.0754 | -31.3 | 0.0283 | -41.3 | 0.0024 |
IL-8 | 55.1 | 0.0879 | 19.2 | 0.4961 | -4.8 | 0.8475 |