Figure 5
In H . bilis -infected Mdr1a−/−mice, changes in protein and gene expression of Cxcl10 (IP-10) correlated with histopathology scores. IBD scores are shown in the left column for the subsets of mice used in each analysis for expression of C-X-C motif chemokine 10 (CXCL10, also known as Interferon gamma-induced protein 10 (IP-10)). The middle column shows serum and colon protein concentrations and colon mRNA levels for the mice in the left column. The graphs in the right column show the comparisons between protein/mRNA and IBD scores (total IBD scores for serum and proximal colon IBD scores for colon explant and mRNA analysis). Mean values for each group are shown for the left and middle columns (horizontal line) as well as statistical significance between groups (analyzed as in Figure 1; *p < 0.05, **p < 0.001, ***p <0.0001). For serum analysis, a least detectable dose was determined for each analyte, and values at or below the limit of detection were assigned a value of one below the least detectable dose for graphing and statistical analysis.