Figure 2

Permeability and apoptotic responses. Total BAL protein (A) and whole lung caspase-3 activity (B) in mice 24 h following the intratracheal administration of LPS (150 ng/gm) or PBS. Some of the mice received doxycycline, 2 mg/kg in the drinking water starting 72 h prior to the administration of LPS. LPS caused an increase in total BAL protein and in the lung caspase-3 activity, which was independent of doxy. n: PBS = 3; Doxy = 5, LPS = 5, LPS + Doxy = 6.