Table 1 Assessment of serum metabolic parameters in diet-induced obese mice post-HFC initiation.

Epididymal

fat pad, %

5.6 (0.8)

2.8 (0.1)

2.0

2.6 (0.2)*

3.8 (0.3)

0.7

2.4 (0.3)**

4.2 (0.4)

0.6

Mesenteric

fat pad, %

1.6 (0.1)*

0.9 (0.1)

1.8

2.1 (0.1)

1.6 (0.2)

1.3

1.9 (0.1)

1.9 (0.2)

1.0

Liver, %

3.6 (0.3)

3.7 (2)

1.0

7.3 (0.4)*

4.5 (0.4)

1.6

7.1 (0.4)*

4.6 (0.1)

1.5

ALT, U/ml

17 (2)

24 (3)

0.7

151 (24)*

31 (2)

4.9

76 (12)*

8 (1)

9.5

glucose, mmol/l

10.24 (0.25)

8.52 (0.25)

1.2

15.13 (0.54)

14.04 (0.46)

1.1

11.35 (0.28)

11.54 (0.34)

1.0

insulin, pmol/l

41.96 (2.81)*

28.85 (6.17)

1.5

436.49 (86.01)*

74.22 (9.97)

5.9

490.22 (55.19)*

278.26 (36.93)

1.8

HOMA

3.19 (0.24)*

1.92 (0.47)

1.7

47.83 (9.26)*

7.76 (1.14)

6.2

39.10 (3.35)*

24.12 (3.53)

1.6

adiponectin, μg/ml

6.7 (0.7)

6.0 (1)

1.1

12 (0.4)*

16 (0.8)

0.8

23 (3)

21 (2)

1.1

leptin, ng/ml

43 (10)*

0.5 (0.2)

86. 0

22 (6)*

4 (1)

5.5

46 (8)*

17 (3)

2.7

MCP-1, pg/ml

32 (2)*

26 (2)

1.2

36 (2)*

23 (2)

1.6

302 (26)*

134 (8)

2.3

IL-6, pg/ml

7 (1)

6 (1)

1.2

25 (6)*

12 (2)

2.1

33 (9)*

17 (5)

1.9

KC, pg/ml

32 (2)

21 (1)

1.5

67 (4)

44 (8)

1.5

98 (12)*

45 (4)

2.2

IL-10, pg/ml

15 (2)

27 (6)

0.6

124 (43)

47 (6)

2.6

45 (17)*

17 (6)

2.6

serum amyloid A

μg/ml

1.1 (0.02)

0.5 (0.2)

2.2

1.6 (0.7)

0.81 (0.05)

2.0

1.85 (0.2)*

0.43 (0.06)

4.3