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Table 1 Assessment of serum metabolic parameters in diet-induced obese mice post-HFC initiation.

From: Inflammatory Signals shift from adipose to liver during high fat feeding and influence the development of steatohepatitis in mice

Parameter   6 weeks    16 weeks    26 weeks  
  HFC Chow fold change HFC Chow fold change HFC Chow fold change
Epididymal          
fat pad, % 5.6 (0.8) 2.8 (0.1) 2.0 2.6 (0.2)* 3.8 (0.3) 0.7 2.4 (0.3)** 4.2 (0.4) 0.6
Mesenteric          
fat pad, % 1.6 (0.1)* 0.9 (0.1) 1.8 2.1 (0.1) 1.6 (0.2) 1.3 1.9 (0.1) 1.9 (0.2) 1.0
Liver, % 3.6 (0.3) 3.7 (2) 1.0 7.3 (0.4)* 4.5 (0.4) 1.6 7.1 (0.4)* 4.6 (0.1) 1.5
ALT, U/ml 17 (2) 24 (3) 0.7 151 (24)* 31 (2) 4.9 76 (12)* 8 (1) 9.5
glucose, mmol/l 10.24 (0.25) 8.52 (0.25) 1.2 15.13 (0.54) 14.04 (0.46) 1.1 11.35 (0.28) 11.54 (0.34) 1.0
insulin, pmol/l 41.96 (2.81)* 28.85 (6.17) 1.5 436.49 (86.01)* 74.22 (9.97) 5.9 490.22 (55.19)* 278.26 (36.93) 1.8
HOMA 3.19 (0.24)* 1.92 (0.47) 1.7 47.83 (9.26)* 7.76 (1.14) 6.2 39.10 (3.35)* 24.12 (3.53) 1.6
adiponectin, μg/ml 6.7 (0.7) 6.0 (1) 1.1 12 (0.4)* 16 (0.8) 0.8 23 (3) 21 (2) 1.1
leptin, ng/ml 43 (10)* 0.5 (0.2) 86. 0 22 (6)* 4 (1) 5.5 46 (8)* 17 (3) 2.7
MCP-1, pg/ml 32 (2)* 26 (2) 1.2 36 (2)* 23 (2) 1.6 302 (26)* 134 (8) 2.3
IL-6, pg/ml 7 (1) 6 (1) 1.2 25 (6)* 12 (2) 2.1 33 (9)* 17 (5) 1.9
KC, pg/ml 32 (2) 21 (1) 1.5 67 (4) 44 (8) 1.5 98 (12)* 45 (4) 2.2
IL-10, pg/ml 15 (2) 27 (6) 0.6 124 (43) 47 (6) 2.6 45 (17)* 17 (6) 2.6
serum amyloid A          
μg/ml 1.1 (0.02) 0.5 (0.2) 2.2 1.6 (0.7) 0.81 (0.05) 2.0 1.85 (0.2)* 0.43 (0.06) 4.3
  1. Assessment was done at the termination point of 6, 16 or 26 weeks post-HFC initiation.
  2. Values are means (sem), n = 14-20 per group. * confidence interval = 95%; ** confidence interval = 99%.
  3. The fold change is calculated as the level in HFC group divided by the level obtained from the Chow group.
  4. The levels of GM-CSF, TNF-α, IL-12p70 and IL-1β were below detection limit of the assays.