Figure 2

Non-development of composite asthma phenotype in ELP-/- mice. Figure 2A. Pulmonary function test by non-invasive whole body plethysmography. Functional response to increasing doses of methacholine show no increase in response from baseline in ELP-/- mice in comparison with WT post-OVA. WT+alum (white square), WT+OVA (black square), ELP-/-+alum (white square) and ELP-/-+OVA (black square). Figure 2B. Pulmonary function test by invasive plethysmography. Functional response to increasing doses of methacholine show no increase in response from baseline in ELP-/- mice in comparison with WT post-OVA. [WA = WT with alum and saline treatment, EA = ELP-/- mice same placebo treatment, WO = WT sensitized and challenged with OVA, EO = OVA treatment with ELP-/- mice.] WA (white square), WO (black square), EA (white triangle), EO (black triangle). Figure 2C. Lung histology. Panel a, b. H&E staining of paraffin lung sections. a. WT+OVA, b. ELP-/-+OVA; Panel c, d. Alcian blue staining of paraffin lung sections. C. WT+OVA, d. ELP-/-+OVA.