Figure 3
Effects of WIN62577 on intracellular Ca2+ concentration ([Ca2+] i ). The ratio of the intensities of emission (R340/380) in control group was 0.2(Fig.3A), but in asthma group the ratio is 1.25, which suggest that the calcium concentration in asthma group was higher than the one in control group (Fig.3B); C and D: representive the cell induced before and after substance P. calcium concentration in ASMC was increasing intervened by substance P, the calcium concentration of asthmatic rat ASMC was decreasing intervened by substance P receptor antagonist. E and F: representive the cell induced before and after WIN62577.