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Table 1 In vitro inhibitory effect (expressed as IC50) of the antibiotics tested against PAF-induced aggregation of WRPs and their ability to induce platelet aggregation

From: In vitro anti-inflammatory and anti-coagulant effects of antibiotics towards Platelet Activating Factor and thrombin

 

IC501towards PAF in WRPs (μg/mL)

 

Bioactive

Compound

Median

Min

Max

Geometric Mean

95% Confidence Interval

Drug-induced WRPs aggregation/desensitization

Clarithromycin

0.18

0.14

0.28

0.19

0.08 thru 0.46

-/-

Azithromycin

0.40

0.20

0.85

0.41

0.07 thru 2.46

-/-

Linezolid

1.25

0.60

1.62

1.07

0.30 thru 3.84

-/-

Amikacin

2.73

1.50

4.55

2.65

0.67 thru 10.54

-/-

Netilmicin

2.80

1.45

4.70

2.67

0.62 thru 11.56

-/-

Daptomycin

5.01

2.88

7.22

4.71

1.49 thru 14.85

-/-

Piperacillin/Tazobactam

17.65/2.22

12.18/1.54

22.27/2.85

16.85/2.14

7.91 thru 35.90/0.99 thru 4.61

-/-

Ceftazidime

30.06

20.92

37.95

28.79

13.66 thru 60.68

-/-

Tigecycline

113.45

91.86

131.07

110.95

71.16 thru 173.0

-/-

Vancomycin

ND

-

-

-

-

+/-

Meropenem

ND

-

-

-

-

-/-

  1. Experiments were conducted three times using different platelets preparations. 1IC50 values are expressed as μg/mL of bioactive compound in the aggregometer cuvette, Final concentration of PAF in the aggregometer cuvette when tested in WRPs was 4.4 × 10-11M. WRPs: Washed Rabbit Platelets; ND: Not detected inhibition against PAF-induced platelet aggregation; -/-: Not detected platelet aggregation; +/-: Detected platelet aggregation/not detected platelet desensitization against PAF.
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Journal of Inflammation

ISSN: 1476-9255

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