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Table 2 Patient characteristics, basline vital signs, hemodynamics and laboratories by lactate clearance quartile.

From: Early lactate clearance is associated with biomarkers of inflammation, coagulation, apoptosis, organ dysfunction and mortality in severe sepsis and septic shock

 

Quartile 1

N = 55

Quartile 2

N = 55

Quartile 3

N = 55

Quartile 4

N = 55

P-value

Lactate clearance (%)

- 24.3 ± 42.3

30.1 ± 7.5

53.4 ± 6.6

75.1 ± 7.1

<0.01

Age (years)

63.2 ± 16.5

68.2 ± 17.5

65.7 ± 15.7

66.7 ± 18.4

0.29

Septic shock (%)

70.9

58.2

54.6

36.4

<0.01

Culture positive (%)

45.5

33.3

42.6

32.7

0.41

Blood culture positive (%)

43.4

34.0

42.3

28.9

0.36

Vital signs and hemodynamics

   Temperature (°C)

36.3 ± 3.0

36.5 ± 3.2

36.1 ± 2.7

36.4 ± 2.5

0.67

   Heart rate (beats per min)

113.8 ± 25.4

117.0 ± 27.6

120.0 ± 30.9

117.8 ± 36.0

0.70

   Systolic blood pressure (mm Hg)

108.0 ± 39.7

103.3 ± 30.2

108.1 ± 35.0

110.4 ± 40.0

0.88

   Mean arterial pressure (mm Hg)

76.1 ± 26.6

71.2 ± 21.8

75.8 ± 26.9

76.1 ± 27.4

0.81

   Shock index (HR/SBP)

1.2 ± 0.5

1.2 ± 0.4

1.2 ± 0.5

1.2 ± 0.6

0.76

   Respiratory rate (breaths per min)

29.5 ± 10.3

30.4 ± 10.9

34.2 ± 11.8

32.2 ± 10.9

0.16

   CVP (mm Hg)

6.0 ± 8.7

4.5 ± 8.7

3.9 ± 8.9

5.7 ± 8.2

0.16

   ScvO2 (%)

49.3 ± 12.9

51.4 ± 12.0

44.1 ± 12.6

51.2 ± 12.3

0.28

Laboratories

   White blood cells (×103 per mm3)

11.8 ± 7.1

13.5 ± 8.9

15.0 ± 10.5

15.6 ± 9.1

0.13

   Hemoglobin (g/dL)

11.6 ± 2.6

11.0 ± 2.9

11.5 ± 2.5

11.3 ± 2.7

0.68

   Platelets (×103 per μL)

163.7 ± 82.2

184.0 ± 116.7

254.1 ± 135.6

244.4 ± 124.8

<0.01

   Creatinine (mg/dL)

2.5 ± 2.2

2.5 ± 1.7

2.6 ± 1.9

2.7 ± 2.4

0.94

   Glucose (mg/dL)

303.5 ± 421.4

172.1 ± 150.6

240.9 ± 275.0

321.1 ± 382.0

0.07

   Anion gap (mEq/L)

22.2 ± 9.6

20.0 ± 7.3

21.5 ± 7.9

22.2 ± 6.9

0.52

   Total bilirubin (mg/dL)

1.9 ± 2.3

1.9 ± 3.1

1.2 ± 1.4

0.9 ± 0.7

0.03

   Albumin (g/dL)

2.7 ± 0.7

2.8 ± 0.7

2.8 ± 0.7

3.1 ± 0.6

<0.01

   Lactate (mmol/L)

7.5 ± 5.8

7.3 ± 4.9

7.3 ± 3.8

7.3 ± 3.5

0.47

  1. Lactate clearance - defined as the percent change in lactate level after six hours from baseline measurement = [(LactateED Presentation - LactateHour 6)/LactateED Presentation] × 100. A positive value denotes a decrease or clearance of lactate, whereas a negative value denotes an increase in lactate after 6 hours of intervention. Lactate clearance quartile - derived from sorting the study population by increasing lactate clearance and separating into four groups with equivalent number of patients. HR - heart rate; SBP - systolic blood pressure; CVP - central venous pressure; ScvO2 - central venous oxygen saturation.
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Journal of Inflammation

ISSN: 1476-9255

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