Figure 4
From: HE3286, an oral synthetic steroid, treats lung inflammation in mice without immune suppression
Effect of HE3286 on bacterial infection. Female BALB/c mice (n = 8-10 per group) received daily 0.1 mL administrations (gavage) of HE3286 at 80 mg/kg in vehicle (HERF405), equal volumes of vehicle alone, daily IP administrations of dexamethasone (dex; 0.4 mg/kg) in 0.1 mL saline or sham treated. After 14 days of treatment, infection was induced by SC inoculation of 107 colony-forming units (cfu) of K. pneumoniae. Daily HE3286 or dex treatments continued and all animals monitored twice-daily until the end of the study for health status.