Smoking status and tumor necrosis factor-alpha mediated systemic inflammation in COPD patients

Journal of Inflammation

Table 2 Systemic inflammation in never-smoker controls, current smokers controls, COPD ex-smokers and COPD current smokers

	Never-smoker controls N = 34	Current smoker controls N = 24	COPD ex-smokers N = 53	COPD current smokers N = 24
TNF-α(pg/mL)	3.7 (3.4-4.0)	4.8 (4.2-6.1) *	4.3 (3.9-4.9) ^‡	4.8(4.2-5.8) *
IL-6 (pg/mL)	0.35 (0.21-0,44)	0.42 (0.29-0.81)	0.88 (0.52-1.41) ^‡†	0.83(0.46-1.33) ^‡
IL-8 (pg/mL)	5.47 (4.45-7.85)	5.68 (4.32-8.35)	5.53 (3.87-11.82)	5.77(3.87-10.53)
CRP (pg/L)	1.10 (0.62-2.00)	1.07 (0.56-2.54)	4.65 (1.62-7.92) ^‡†	6.85(2.97-9.39)^‡†

TNF-α:Tumor necrosis factor alpha, IL-6: interleukin 6, IL-8: interleukin 8, CRP: C-reative protein. Kruskal-Wallis test followed by Dunn's Method to account for multiple comparisons.
* p < 0.05 when compared to never-smoker controls and COPD ex-smokers. ^‡ p < 0.05 when compared to never-smoker controls. ^† p < 0.05 when compared to current smoker controls.

ISSN: 1476-9255