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Table 1 Demographics, lung function, and body composition of never-smoker controls and current smoker controls and COPD patients, according to smoking status

From: Smoking status and tumor necrosis factor-alpha mediated systemic inflammation in COPD patients

  Never-smoker controls
N = 34
Current smokers
controls
N = 24
COPD
ex-smokers
N = 53
COPD
Current smokers
N = 24
p value
Age (years) 49.1 ± 8.3 48.6 ± 6.6 66.5 ± 7.7* 57.5 ± 9.3†† <0.001
Gender (M/F%) 50/50 58/42 75/25§ 46/54§ 0.03
FEV1 (L) 3.3 ± 0.7 2.9 ± 0.8 1.3 ± 0.7* 1.5 ± 0.9* <0.05
FEV1 (%) 111.2 ± 15.2 105.4 ± 16.2 56.3 ± 25.5* 59.4 ± 22.1* <0.001
FVC (L) 4.0 ± 0.9 3.8 ± 0.8 2.7 ± 0.8* 2.7 ± 1.1* <0.05
FVC (%) 110.8 ± 14.4 111.6 ± 16.9 90.8 ± 24.1* 89.5 ± 19.9* <0.001
FEV1/FVC (%) 83.2 ± 14.8 78.0 ± 4.9 49.0 ± 12.8* 53.5 ± 12.1* <0.05
Packs-year 0.0(0.0-0.0) 30.0(21.3-40.0) 50.0(29.1-62.5) 44.0(32,0-60.0) <0.05
SpO2 (%) 96.6 ± 1.4 96.5 ± 1.5 91.2 ± 5.5* 93.4 ± 3.6* <0.05
BMI (kg/m2) 25.5 ± 3.3 23.8 ± 3.9 25.4 ± 5.5 25.1 ± 4.7 0.48
FFM (kg) 46.3 ± 8.6 44.6 ± 7.4 42.0 ± 7.4 38.3 ± 7.1 0.01
FFMI (kg/m2) 17.3 ± 1.8 16.5 ± 1.9 16.1 ± 2.4 15.3 ± 1.9 0.005
  1. Values are expressed as mean (SD) or median (range).
  2. Differences between groups were tested using one way analysis of variance (ANOVA) followed by the Tukey test to account for multiple comparisons. Differences between proportions were tested using Chi-square.
  3. * compared to never-smoker controls and current smokers controls. compared to never-smoker controls. †† compared to never-smoker controls, current smoker controls and ex-smokers COPD. § difference in proportion of gender within COPD groups.
  4. M/F: male/female, FVC: forced vital capacity, FEV1: forced expiratory volume in the first second, SpO2: percentage arterial oxygen saturation, BMI: body mass index, FFM: fat free mass, FFMI: fat free mass index.