From: Smoking status and tumor necrosis factor-alpha mediated systemic inflammation in COPD patients
 | Never-smoker controls N = 34 | Current smokers controls N = 24 | COPD ex-smokers N = 53 | COPD Current smokers N = 24 | p value |
---|---|---|---|---|---|
Age (years) | 49.1 ± 8.3 | 48.6 ± 6.6 | 66.5 ± 7.7* | 57.5 ± 9.3††| <0.001 |
Gender (M/F%) | 50/50 | 58/42 | 75/25§ | 46/54§ | 0.03 |
FEV1 (L) | 3.3 ± 0.7 | 2.9 ± 0.8 | 1.3 ± 0.7* | 1.5 ± 0.9* | <0.05 |
FEV1 (%) | 111.2 ± 15.2 | 105.4 ± 16.2 | 56.3 ± 25.5* | 59.4 ± 22.1* | <0.001 |
FVC (L) | 4.0 ± 0.9 | 3.8 ± 0.8 | 2.7 ± 0.8* | 2.7 ± 1.1* | <0.05 |
FVC (%) | 110.8 ± 14.4 | 111.6 ± 16.9 | 90.8 ± 24.1* | 89.5 ± 19.9* | <0.001 |
FEV1/FVC (%) | 83.2 ± 14.8 | 78.0 ± 4.9 | 49.0 ± 12.8* | 53.5 ± 12.1* | <0.05 |
Packs-year | 0.0(0.0-0.0) | 30.0(21.3-40.0)†| 50.0(29.1-62.5)†| 44.0(32,0-60.0)†| <0.05 |
SpO2 (%) | 96.6 ± 1.4 | 96.5 ± 1.5 | 91.2 ± 5.5* | 93.4 ± 3.6* | <0.05 |
BMI (kg/m2) | 25.5 ± 3.3 | 23.8 ± 3.9 | 25.4 ± 5.5 | 25.1 ± 4.7 | 0.48 |
FFM (kg) | 46.3 ± 8.6 | 44.6 ± 7.4 | 42.0 ± 7.4 | 38.3 ± 7.1†| 0.01 |
FFMI (kg/m2) | 17.3 ± 1.8 | 16.5 ± 1.9 | 16.1 ± 2.4 | 15.3 ± 1.9†| 0.005 |