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Table 3 The basic pharmacokinetic parameters of linezolid and ertapenem in pleural fluid and in blood serum after the i.v. infusion of linezolid solution (10 mg/kg) and of ertapenem solution (60 mg/kg) to 10 and 8 New Zealand white rabbits, respectively.

From: Pharmacokinetics of Linezolid and Ertapenem in experimental parapneumonic pleural effusion

 

Blood serum

Pleural fluid

Rpf/ser

Linezolid

AUC 0-8 h (h.mcg/mL)

2.20

9.45

4.29

AUC 0-inf (h.mcg/mL)

2.24

9.72

4.34

T 1/2 (hours)

0.98

1.18

 

Ertapenem

AUC 0-8 h (h.mcg/mL)

12.70

17.74

1.39

AUC 0-inf (h.mcg/mL)

12.77

18.76

1.47

T 1/2 (hours)

1.03

1.49

 
  1. AUC 0-8 h/0-inf : area under the linezolid/ertapenem concentration versus time curve corresponding to 0-8 hours and 0-inf time intervals, respectively. T 1/2 : terminal elimination half-life, of linezolid/ertapenem in pleural fluid and in blood serum. R pf/ser : linezolid/ertapenem penetration ratio into the pleural fluid compared to blood serum.
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Journal of Inflammation

ISSN: 1476-9255

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