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Table 3 The basic pharmacokinetic parameters of linezolid and ertapenem in pleural fluid and in blood serum after the i.v. infusion of linezolid solution (10 mg/kg) and of ertapenem solution (60 mg/kg) to 10 and 8 New Zealand white rabbits, respectively.

From: Pharmacokinetics of Linezolid and Ertapenem in experimental parapneumonic pleural effusion

  Blood serum Pleural fluid Rpf/ser
Linezolid
AUC 0-8 h (h.mcg/mL) 2.20 9.45 4.29
AUC 0-inf (h.mcg/mL) 2.24 9.72 4.34
T 1/2 (hours) 0.98 1.18  
Ertapenem
AUC 0-8 h (h.mcg/mL) 12.70 17.74 1.39
AUC 0-inf (h.mcg/mL) 12.77 18.76 1.47
T 1/2 (hours) 1.03 1.49  
  1. AUC 0-8 h/0-inf : area under the linezolid/ertapenem concentration versus time curve corresponding to 0-8 hours and 0-inf time intervals, respectively. T 1/2 : terminal elimination half-life, of linezolid/ertapenem in pleural fluid and in blood serum. R pf/ser : linezolid/ertapenem penetration ratio into the pleural fluid compared to blood serum.