Table 3 The basic pharmacokinetic parameters of linezolid and ertapenem in pleural fluid and in blood serum after the i.v. infusion of linezolid solution (10 mg/kg) and of ertapenem solution (60 mg/kg) to 10 and 8 New Zealand white rabbits, respectively.
AUC0-8 h/0-inf : area under the linezolid/ertapenem concentration versus time curve corresponding to 0-8 hours and 0-inf time intervals, respectively. T1/2: terminal elimination half-life, of linezolid/ertapenem in pleural fluid and in blood serum. Rpf/ser : linezolid/ertapenem penetration ratio into the pleural fluid compared to blood serum.