|Type of study||Results|
|Imaging neural regulation of NF-κB||
Hepatic NF-κB is crucial for recruitment of neutrophils to the injured brain .|
Vagus nerve signaling regulates NF-κB activity .
|Imaging of infection models||
In vivo imaging of NF-κB in lung .|
NF-κB is sufficient to cause lung inflammation .
Duration of NF-κB activity is determining for lung injury .
Bacterial lung infection induces NF-κB. Lack of oxidative burst and targeted inhibition of NF-κB worsens Pseudomonas infection [38, 39].
NF-κB is induced in infected mammary glands .
NF-κB is central for regulating milk production of mammary glands .
|Imaging autoimmune disease||
In vivo imaging of NF-κB during arthritis .|
Tracking NF-κB in a transgenic model with various autoimmune diseases .
Evaluation of NF-κB inhibitor in arthritis. Combined imaging of NF-κB activity and protease specific near infrared probe .
Evaluation of probe for reactive oxygen species and NF-κB activity in arthritis .
|Imaging of dietary influence||
NF-κB activity during high fat feeding and obesity .|
NF-κB and its role in energy balance of obese mice .
Vitamin A regulates NF-κB activity .
|Imaging host immune reaction||Interaction between host and biomaterial induces NF-κB |
|Imaging TGFβ signaling||
Imaging Smad2/3-dependent TGF-beta signaling reveals prominent tissue-specific responses to inflammatory stimulus and injury .|
Orally administered TGF-beta is biologically active in the intestinal mucosa and enhances oral tolerance .
Imaging of Smad signaling shows correlation with excitotoxic neurodegeneration .
|Imaging regulation through natural promoters of inflammatory genes||
iNOS-promoter activity used to evaluate effect of anti-inflammatory compounds .|
Regulation of IκBα expression involves both the NF-κB and MAP kinase signaling pathways .
Serum amyloid A is induced by inflammatory stimuli. NF-κB is an important regulator .
GADD45β-promoter regulation by NF-κB and not MAPK pathway in acute inflammation .
Imaging Cox-2 gene expression in living animals with a luciferase knock-in reporter gene .
|Imaging inflammation in non-conventional transgenic mice||
NF-κB activation during liver inflammation in mice and prevention by catalase delivery .|
Real-time imaging of ligand-induced IKK activation in liver .
Viral delivery of reporter constructs to discrete brain region used to monitor longitudinal NF-κB and AP1 activity .