CCR5 signalling, but not DARC or D6 regulatory, chemokine receptors are targeted by herpesvirus U83A chemokine which delays receptor internalisation via diversion to a caveolin-linked pathway

Table 1 Human chemokines and their receptors targeted by early HHV-6A infection

HHV-6A protein	Bound* chemokines	Displaced* chemokines	Affected* signalling Receptors	Affected scavenger receptors
U51A receptor	CCL2		CCR2	DARC, D6
	CCL5		CCR1, 3, 5	DARC, D6**
	CCL7		CCR1, 2, 3	DARC, D6
	CCL13		CCR1, 2, 3	DARC, D6
	CCL11		CCR3	DARC, D6
	CCL19		CCR7	CCX-CKR
	XCL1		XCR1	-
**U83A chemokine		CCL3, 5	CCR1	DARC, D6
		CCL17, 22	CCR4	D6
		CCL3, 4, 5	CCR5	DARC, D6
		CCL20	CCR6	-
		CCL1	CCR8	-

ISSN: 1476-9255