Figure 4

TNF-α secretion induced by exposure to glycol-derived compounds. TNF-α secretion (ELISA, in pg/ml) of human T24 cells exposed during 48 hours to increasing osmolarities (300, 600, 900 mOsm) of different compounds: A) Mannitol (300 mOsm [69.40–174.15]; 600 mOsm [214.92–247.70]; 900 mOsm [464.06–829.81]); B) Propylene Glycol (300 mOsm [69.40–174.15]; 600 mOsm [90.364–236.51]; 900 mOsm [232.68–443.57]); C) Glycerol (300 mOsm [69.40–174.15]; 600 mOsm [140.36–351.25]; 900 mOsm [402.68–632.45]). For each group, the horizontal bar is the median. Upper values represent the global p-values (Kruskal-Wallis test). The p-value given by the Tukey test above a stripchart indicates the result of the comparison of this group versus control. CI at 95% are given in parentheses (n = 5).