Inhibition of zymosan-induced kidney dysfunction by tyrphostin AG-490

Journal of Inflammation

Table 1 Effect of AG-490 on the MIP-1α, RANTES and IL-10 levels in peritoneum and plasma

Groups^a	MIP-1α (pg/ml)		RANTES (pg/ml)		IL-10 (pg/ml)
	peritoneum	plasma	peritoneum	plasma	peritoneum	plasma
Control	120 ± 28	140 ± 28	145 ± 18	80 ± 20	20 ± 2.0	30 ± 1.8
AG-490	120 ± 30	116 ± 15	125 ± 20	65 ± 15	25 ± 2.0	28 ± 2.0
ZY	1200 ± 58	800 ± 48	580 ± 40	220 ± 35	780 ± 88	420 ± 45
ZY+AG-490	280 ± 36*	380 ± 36*	360 ± 50*	160 ± 30	920 ± 86*	640 ± 54*

^aThe peritoneum and plasma level of mediators was determined in healthy mice treated with vehicle (Control) or AG-490 (AG-490) and in shock mice treated with vehicle (ZY) or AG-490 (ZY+AG-490). The plasma and peritoneal fluid were collected 4 h after zymosan injection. Data are expressed as mean ± SD (n = 5/group) and were compared by Student's t test. *p < 0.01 versus zymosan-injected group.

ISSN: 1476-9255