Figure 3
From: Inhibition of zymosan-induced kidney dysfunction by tyrphostin AG-490
Effect of AG-490 on the production of IL-6 and MIP-1α in plasma and on the renal expression of STAT1 and STAT3. A-B, AG-490 diminished the plasma levels of IL-6 and MIP-1α on day 21 of zymosan injection. The data represent the mean ± SD from 3 independent experiments (5 mice/group); *p < 0.05 and **p < 0.01 versus zymosan-injected group; Student's t test. C-D, The representative data from 1 experiment (n = 5/group) showed increased STAT1 (indicated with arrows on C; 1 × 400) and STAT3 expression in kidneys (indicated with arrows on D; 1 × 400) on day 21 of zymosan injection (ZY group). The administration of AG-490 decreased the renal expression of both transcription factors (C-D; ZY+AG-490).