Figure 1

Effect of AG-490 on zymosan-induced inflammation. A, The administration of AG-490 (5 mg/kg) increased the survival rate of mice injected with 1 mg/g body weight of zymosan (n = 15/group). B, AG-490 inhibited the level of C5a in peritoneal lavage and in plasma 4 h after zymosan injection. C-D, AG-490 rendered the time of coagulation and the plasma level of α1-antitrypsin to normal range 4 h after the induction of shock. The data represent mean ± SD from 3 independent experiments with 5 mice/group; *p < 0.05, **p < 0.01 and ***p < 0.001; Control groups of healthy mice were treated with vehicle (control) or AG-490 (AG-490), shock mice were treated with vehicle (ZY) or with AG-490 (ZY+AG-490); ANOVA test was used to analyze the survival data and Student's t test to compare other parameters.