P38 MAP kinase inhibitors as potential therapeutics for the treatment of joint degeneration and pain associated with osteoarthritis

Table 1 In vitro inhibitory effects of SB-203580 and VX-745 on p38 and cytokine release

^aHuman p38α kinase was assayed using ATF2.
^bTNFα release from the human monocytic cell line THP-1 was measured by ELISA 4 h after stimulation with LPS.
^cTNFα and IL-1β release from human peripheral blood mononuclear cells was measured by ELISA 16 h after stimulation with LPS. All data are expressed as the mean ± S.D.

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