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Figure 7 | Journal of Inflammation

Figure 7

From: Chondroprotective effects of a proanthocyanidin rich Amazonian genonutrient reflects direct inhibition of matrix metalloproteinases and upregulation of IGF-1 production by human chondrocytes

Figure 7

MMP activity from culture media of IL-1β treated human chondrocytes and the inhibitory effects of progrado. Subconfluent human chondrocytes were treated with IL-1β (10 ng/ml) to stimulate the release of matrix metalloproteinases, measured as MMP and MMP-9 using gelatin zymography. Progrado was associated with a dose-dependent inhibition of both MMP-2 and MMP-9 activity. Complete inhibition of MMP-9 was evident at 4 μg/ml, with MMP-2 activity reduced by approximately 90%.

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Journal of Inflammation

ISSN: 1476-9255

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