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Table 2 Total and differential cell counts of BAL fluid from MMP-12 -/- and WT mice 14 days after intranasal administration of bleomycin (BLM) or saline vehicle (Control). Results are presented as the mean (.103 cells) ± SEM. n: number of mice. a: P < 0.05, b: P < 0.01, c: P < 0.001 compared with control mice exposed to saline solution only.

From: Macrophage metalloelastase (MMP-12) deficiency does not alter bleomycin-induced pulmonary fibrosis in mice

Treatment

Strain

N

Total cells

Macrophages

Neutrophils

Eosinophils

Lymphoytes

Control

WT

5

579 ± 92

561 ± 79

13 ± 10

0 ± 0

6 ± 6

 

MMP-12 -/-

5

547 ± 92

540 ± 94

2 ± 2

0 ± 0

4 ± 4

BLM

WT

8

2204 ± 284c

1783 ± 210c

285 ± 78b

55 ± 19b

81 ± 33b

 

MMP-12 -/-

8

1352 ± 355a

1152 ± 255a

104 ± 62b

19 ± 17

76 ± 55