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Figure 1 | Journal of Inflammation

Figure 1

From: Nurr1 dependent regulation of pro-inflammatory mediators in immortalised synovial fibroblasts

Figure 1

Coexpression of a dominant negative-Nurr1 receptor attenuates the transactivation activity of Nurr1-wild type in a β-Gal reporter assay. HeLa cells coexpressing pCDNA3.1-Nurr1-WT and pcDNA3.1-Nurr1-DN in varying ratios demonstrates strong antagonist effects of dominant negative Nurr1 construct on Nurr1 transcriptional activity (pNurRE3gal), values normalised to cotransfected hGH, using an hGH sandwich ELISA assay. Values expressed represent the mean fold change ± SEM, compared to the reporter alone.

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