Figure 2

A dose–response reduction of TNF-α, IL-1β (A) IL-6, IL-8 (B) by RV-D1 in Poly I:C (25 μg/cc) stimulated in HCE cells. For TNF-α and IL-1β detection the HCE cells were incubated in SFM with RV-D1 for 15 hours and cells pre-incubated for 2 hours with RV-D1’s at 1 μM, 0.1 μM and 0.01 μM (A). For IL-6 and IL-8 detection the HCE cells were incubated in SFM with Poly I:C for 4 hours and cells pre-incubated for 2 hours with RV-D1at 1 μM, 0.1 μM, and 0.01 μM (B). For IL-1β and TNF-α the dose response correlation coefficients were >0.942 (p < 0.05).