Figure 1

RV-D1’s Effects on Poly I:C-Induced pro-inflammatory cytokines protein secretion in HCE cells (A-D). For TNF-α and IL-1β detection the HCE cells were stimulated in SFM with Poly I:C (25 μg/cc) for 15 hours and cells pre-incubated for 2 hours with RV-D1 at 1 μM (A, C). For IL-6 and IL-8 detection the HCE cells were stimulated with Poly I:C for 4 hours and cells pre-incubated for 2 hours with RV-D1 at 1 μM (B, D). Data shown is the ratio to stimulus with poly I:C only (mean ± SD) from four independent experiments (n = 4). Asterisks indicate a significant difference (P < 0.05) between groups compared to poly I:C only.