Combination therapy with ampicillin and azithromycin in an experimental pneumococcal pneumonia is bactericidal and effective in down regulating inflammation in mice

Table 1 In vitro susceptibilities of Streptococcus pneumoniae strains to different antimicrobial agents*

Drug	MIC (mg/L)		MBC (mg/L)		Zone diameter (mm)
Drug	ATCC 49619	AMRI SP 1	ATCC 49619	AMRI SP 1	ATCC 49619	AMRI SP 1
PEN	0.06^a	64^b	0.06	-	26	+
AMP	0.25^a	>32^b	0.5	-	20	+
AZM	0.12^a	8^b	2	16	23	10
AMC	0.06^a	2^a	0.12	8	24	22
OXA	0.06^a	0.25^a	0.25	0.5	23	22
CAZ	8^c	16^b	16	>64	23	15
CRO	1^a	2^b	4	4	22	16
CTX	4^a	0.5^a	8	1	23	22
CXM	0.5^a	2^a	1	64	25	23
FEP	0.06^a	0.5^a	0.06	1	25	24
CLI	0.5^a	4^b	0.5	16	17	13
IPM	0.06^a	0.12^a	0.12	1	23	25
MEM	0.06^a	0.06^a	0.12	1	24	24
LVX	0.12^a	16^b	0.12	32	19	12
CIP	0.06^a	1^a	0.12	2	23	25
RIF	0.06^a	0.12^a	0.12	1	20	21
VAN	1^a	>64^b	4	-	19	+
GEN	0.5^a	2	1	4	23	20
TMP-SXT	1^a	>64^b	2	-	18	+

*PEN- Penicillin, AMP- Ampicillin, AZM- Azithromycin, AMC- Amoxicillin/Potassium Clavulanate, OXA- Oxacillin, CAZ- Ceftazidime, CRO- Ceftriaxone, CTX- Cefotaxime, CXM- Cefuroxime, CLI- Clindamycin, IPM- Imipenem, MEM- Meropenem, LVX- Levofloxacin, CIP- Ciprofloxacin, RIF- Rifampin, VAN- Vancomycin, GEN- Gentamicin, TMP-SXT- Trimethoprim/Sulphamethoxazole.
‘-‘Not within the detectable limit; ‘+’ No zone of inhibition detected.
^aSensitive, b: Resistant, c: Intermediate.

ISSN: 1476-9255