Figure 2
From: Differential regulation of anti-inflammatory genes by p38 MAP kinase and MAP kinase kinase 6
Transcriptional and post-transcriptional regulation of IL-10 expression. (a) De novo IL-10 transcription rate was significantly inhibited in p38 inhibitor-treated WT and MKK3−/− cells compared with WT control. MKK6−/− cells expressed IL-10 at a rate comparable to WT control (*p < 0.05). (b) IL-10 mRNA decay in MKK-deficient cells was comparable to WT control. p38 inhibitor-treated WT cells showed a significantly higher rate of IL-10 degradation compared with WT control.