Figure 1
From: TLR2 stimulation induces cardiac inflammation but not cardiac depression in vivo
Time course of inflammatory parameters in hearts of WT- and TLR2-D mice after LTA challenge (15 mg/kg, i.p). A: RT-qPCR of TLR2. Peak expression was detected after 4 h. (*p < 0.05; n = 6; mean ± SEM). B: NFκB-DNA binding activity following LTA stimulation (EMSA). Lipoteichoic acid treatment activated NFκB in WT- but not in TLR2-D mice. The NFκB-complex mainly consisted of p50 and p65 as depicted by supershift assay (EMSA is representative of three animals per group).