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Table 2 Statistically significant plasma biomarker measurements

From: Pediatric sepsis inflammatory blood biomarkers that correlate with clinical variables and severity of illness scores

Biomarker

Healthy Controls (n = 20)

PICU Day-1 Sepsis (n = 20)

PICU Day-2 Sepsis (n = 13)

P-value

G-CSF

0 (0, 56.97)

498.26 (219.98, 5422.09)

426.49 (104.57, 681.23)

< 0.001

IL-1RA

8.32 (3.71, 17.67)

231.23 (126.02, 1075.80)

75.22 (29.60, 224.32)

< 0.001

IL-6

0.67 (0.32, 1.68)

288.22 (59.45, 3472.15)

96.09 (24.35, 311.18)

< 0.001

IL-8

1.70 (1.10, 3.58)

12.79 (6.30, 249.72)

8.70 (5.98, 180.31)

< 0.001

IL-10

3.16 (0, 26.16)

132.62 (30.15, 868.09)

74.32 (23.20, 309.52)

< 0.001

IL-18

39.95 (28.15, 58.54)

87.32 (59.95, 116.55)

86.58 (76.50, 115.00)

< 0.001

MCP-1

224.6 (187.1, 281.8)

1273.3 (724.8, 3637.4)

842.7 (617.1, 4619.6)

< 0.001

M-CSF

14.25 (0.51, 42.50)

240.44 (141.53, 474.90)

209.70 (119.20, 539.35)

< 0.001

MIP-1β

25.98 (19.61, 35.02)

56.85 (38.73, 131.75)

71.72 (38.33, 112.04)

< 0.001

TNFα

22.20 (10.11, 53.54)

119.82 (41.25, 384.94)

73.57 (36.37, 339.42)

< 0.001

RANTES

10,590 (6150, 15,275)

4811 (1939, 6417)

4121 (1356, 4597)

< 0.001

MMP3

7414 (3751, 10,487)

28,604 (21,388, 45,900)

28,600 (19,827, 40,895)

< 0.001

MMP1

413.7 (367.6, 471.7)

1374.5 (761.0, 3800.6)

1099.4 (536.7, 1425.0)

< 0.001

MMP7

3892 (3279, 4360)

7563 (4528, 11,636)

7771 (6136, 13,026)

< 0.001

MMP10

444.2 (312.2, 616.1)

2039.1 (971.6, 4170.0)

2033.7 (1297.2, 4587.0)

< 0.001

Elastase 2

3.01 (1.60, 4.19)

21.23 (13.72, 58.22)

19.79 (8.71, 33.05)

< 0.001

HSP70

21,451 (19,626, 32,424)

124,090 (64,321, 179,781)

144,242 (69,428, 239,501)

< 0.001

MMP8

372.5 (217.7, 513.6)

5089.1 (1129.6, 19915.9)

6009.0 (1623.7, 15444.8)

< 0.001

Hyaluronan

20.10 (14.85, 46.24)

137.98 (85.20, 362.31)

106.24 (55.31, 538.60)

< 0.001

NGAL

60.86 (45.58, 95.74)

223.05 (132.35, 1651.90)

294.48 (134.41, 2063.79)

< 0.001

Resistin

9.06 (6.41, 11.71)

61.39 (19.75, 119.30)

30.57 (17.70, 62.13)

< 0.001

MIG

1295 (1013, 2772)

3665 (1959, 13,735)

2776 (1947, 5235)

0.004

MMP9

16,018 (13,471, 18,928)

10,235 (6335, 17,943)

8586 (5882, 15,967)

0.008

MMP2

115,962 (99,215, 133,619)

98,954 (82,197, 106,700)

90,882 (74,505, 109,475)

0.009

  1. Data presented in pg/mL as median (IQR)
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Journal of Inflammation

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