Fig. 2

Crtc1 knockout alleviated CLP-induced apoptosis in ALI.(A, B) Representative TUNEL staining images (A) and quantification data (B) showing the impact of Crtc1 KO on CLP-induced apoptosis in lung tissues. ^***P < 0.001 vs. Crtc1^+/+; ^###P < 0.001 vs. Sham. n = 6. (C-F) Western blot (C) and quantification (D-F) showing the protein level of Cleaved-caspase3/Caspase3 (D), Bcl-2 (E) and Bax (F) in mice lung tissues. ^*P < 0.05, ^**P < 0.01 vs. Crtc1^+/+; ^#P < 0.05, ^##P < 0.01 vs. Sham; n = 3