Table 1 Quantification of relative protein expression of senescence markers, MMP-2, and proteins of NF-κB, MAPKs, and mTOR pathways One way-ANOVA followed by Tukey’s test

1.00 ± 0.08

0.90 ± 0.06

1.03 ± 0.06

0.94 ± 0.05

0.1359

1.00 ± 0.08

0.52 ± 0.04

0.79 ± 0.08

0.94 ± 0.02

0.0001

1.00 ± 0.03

0.64 ± 0.03

0.87 ± 0.04

0.88 ± 0.05

0.0001

1.00 ± 0.04

2.10 ± 0.09

1.06 ± 0.11

1.40 ± 0.09

0.0001

1.00 ± 0.05

0.91 ± 0.03

1.01 ± 0.03

1.02 ± 0.05

0.0360

1.00 ± 0.11

0.86 ± 0.02

1.01 ± 0.06

1.03 ± 0.02

0.0371

1.00 ± 0.02

2.43 ± 0.41

0.88 ± 0.02

1.44 ± 0.22

0.0001

1.00 ± 0.22

1.05 ± 0.08

1.04 ± 0.13

1.28 ± 0.05

0.1208

1.00 ± 0.04

2.67 ± 0.36

0.87 ± 0.02

1.41 ± 0.15

0.0001

1.00 ± 0.10

1.22 ± 0.10

1.03 ± 0.06

1.24 ± 0.03

0.0098

1.00 ± 0.10

4.42 ± 0.87

0.80 ± 0.17

1.65 ± 0.12

0.0001

1.00 ± 0.07

1.86 ± 0.23

1.21 ± 0.18

1.22 ± 0.10

0.0009

1.00 ± 0.13

3.28 ± 0.31

0.67 ± 0.11

1.05 ± 0.15

0.0001

1.00 ± 0.17

3.28 ± 0.12

1.02 ± 0.20

0.94 ± 0.18

0.0001

1.00 ± 0.02

1.01 ± 0.03

1.01 ± 0.02

1.03 ± 0.02

0.3316

1.00 ± 0.03

0.94 ± 0.02

0.90 ± 0.04

0.91 ± 0.02

0.0090

1.00 ± 0.08

2.55 ± 0.36

0.79 ± 0.02

1.38 ± 0.10

0.0001

1.00 ± 0.06

1.85 ± 0.06

1.04 ± 0.11

1.03 ± 0.13

0.0001

1.00 ± 0.10

1.30 ± 0.4

1.22 ± 0.14

1.16 ± 0.19

0.1126

1.00 ± 0.13

1.44 ± 0.10

1.37 ± 0.09

1.28 ± 0.12

0.0057

1.00 ± 0.18

1.45 ± 0.07

1.32 ± 0.01

1.11 ± 0.14

0.0058

1.00 ± 0.17

0.96 ± 0.11

1.26 ± 0.08

1.57 ± 0.16

0.0020

1.00 ± 0.01

0.77 ± 0.05

0.99 ± 0.07

0.97 ± 0.03

0.0009

1.00 ± 0.18

0.87 ± 0.01

0.80 ± 0.06

1.10 ± 0.12

0.0547

1.00 ± 0.01

0.94 ± 0.02

1.02 ± 0.02

1.03 ± 0.03

0.0063

1.00 ± 0.08

1.40 ± 0.04

1.32 ± 0.07

1.26 ± 0.07

0.0003

1.00 ± 0.02

0.94 ± 0.06

1.04 ± 0.04

1.05 ± 0.08

0.1575

1.00 ± 0.02

1.91 ± 0.02

1.19 ± 0.01

1.53 ± 0.10

0.0001