Fig. 8
From: Dioscin alleviates the progression of osteoarthritis: an in vitro and in vivo study
Dio alleviated osteoarthritis progression in rat OA models. A The H&E and Safranin-O-Fast green staining demonstrated that the OA group showed obvious damage to the cartilage compared with the sham group. However, the administration of Dio significantly ameliorated the cartilage damage compared with the OA group. B The immunohistochemical staining of collagen II, aggrecan, MMP13 and iNOS also confirmed the positive effects of Dio on cartilage. C The OARSI scores of each group. D Quantitative of collagen II, aggrecan, MMP13, and iNOS in the cartilage samples from each group. #P < 0.05 vs. sham group; **P < 0.01 vs. OA group