Fig. 4

TRPM2 deficiency alleviates paw inflammation and edema induced by MSU crystals. A Representative photographs of paw edema (swelling) after injection into WT and TRPM2^−/− mice of 0.6 mg MSU crystals in 30 μl PBS. Injection of sterile PBS served as controls. B The graph shows the paw edema of WT and TRPM2^−/− mice 6 h and 1-12 d after injection of the MSU crystals analyzed by an electronic vernier scale. Mean ± SD is displayed. The p values at 6 h, 4d, 6d, 7d and 8d are 0.0054, 0.0208, <0.0001, 0.0079 and 0.0083, respectively. C Representative μCT images of WT and TRPM2^−/− mice at d 12. D Representative H&E staining of the paws of WT and TRPM2^−/− mice at d 12. Scale bars, 50 μm