Fig. 3

The domain structure of human STING protein. Human STING is a 379 amino-acid long ER-resident protein. The N-terminal contains 5 membrane-embedded domains (dark blue) including 4 transmembrane domains and Helix α1 responsible for ligand sensing and protein dimerisation. The C-terminal is mainly cytoplasmic (pale blue). It contains the cyclic dinucleotide (CDN) binding domain and interaction sites for TBK1 and IRF3 at the tail. Numbers above STING sequence indicate the amino acids comprising the functional domain